The TiO₂-Pt Nanoparticles Implication in the Immune Response and Their Interaction with the Animal Cell
G.C. CORNEANU, C. CRĂCIUN, M. CORNEANU, C. LAZĂU, I. GROZESCU, I. SILOSI, S. ROGOZ, G.C. PRODAN, L. BARBU-TUDORAN, C. MIHALI, I. ŞTEFĂNESCU, L.-M. CORNEANU

Abstract. TiO₂-Pt nanoparticles were intraperitoneal injected in Mus musculus, exposed or not at a stress factor (X-rays). The TiO₂-Pt nanoparticles stimulated the immune system, conducting to the enhanced of the immunoglobines quantity (IgG, IgM) confirmed by the hemoleukogram values. At the liver level, the TiO₂-Pt nanoparticles were presented in the sinusoid capillaries (circulatory system) and in the Kupffer cells (especially in endoplasmic reticulum, cytoplasm and in vacuoles). The nanoparticles are active eliminated at the unirradiated animals. In irradiated animals, in some Kupffer cells there are not present the TiO₂-Pt nanoparticles, which remain in the circulatory system, activating the immune system.