BASED MICROFLUIDIC PLATFORM FOR BIOMOLECULAR SEPARATION
A. AVRAM, M. AVRAM, M. VOLMER, D. P. POENAR, C. ILIESCU
Abstract. The motivation of the research work is to realize a spin
valve array for manipulating, sorting and testing biomolecules. The spin
valve arrays allow the application of torsion forces to a large number of
individual biomolecules simultaneously. A novel microfluidic platform for
manipulation of micro/nano magnetic particles was designed, fabricated and
tested for applications dealing with biomolecular separation. At the
present moment we are studying of the interaction of the magnetic
particles used in biological applications with the GMR sensor. The
fractional change in resistance, and hence the sensitivity, will be
maximized by matching, as far as possible, the size of the sensor to the
size of the beads and by carefully positioning the beads over the sensor.
We found, by micromagnetic simulations, that the amount of surface
coverage with magnetic particles may affect the magnetization curve of the
sensor and will change the field dependence of his GMR response.